Coffin–Lowry syndrome (CLS) is a rare genetic condition that affects physical development, intellectual functioning, and sometimes behaviour. It is caused by a change (mutation) in a gene on the X chromosome, which means it can affect males more severely, although females can also experience some features.

While every person with Coffin–Lowry syndrome is different, early recognition, the right supports, and a compassionate, person-centred approach can help people with CLS live safe, connected, and meaningful lives.